17-KSR Deficiency

17-KSR deficiency or 17-beta Hydroxysteroid Dehydrogenase 3 Deficiency is an [./https://lgbta.wikia.org/wiki/Intersex intersex] variation that effects 1 in 147,000 newborn [./https://lgbta.wikia.org/wiki/CTM CTM] or [./https://lgbta.wikia.org/wiki/AMAB AMAB] individuals (however those with this condition are also often incorrectly [./https://lgbta.wikia.org/wiki/AFAB assigned female at birth] as well.)

Most with this variation - despite their male chromosomes (XY) - have a vagina, [./https://lgbta.wikia.org/wiki/Ambiguous_Genitalia ambiguous genitals], or a [./https://lgbta.wikia.org/wiki/Agenital micropenis] instead of a penis. Those who do have a penis usually have [./https://lgbta.wikia.org/wiki/Hypospadias an oddly placed urethra]. This means they often also have [./https://lgbta.wikia.org/wiki/AMAB_Hypogonadism hypogonadism] and [./https://lgbta.wikia.org/wiki/Aromatase_Excess_Syndrome aromatase excess syndrome].

Upon puberty, those with this variation usually gain muscle mass, have a deepening voice, facial and body hair, and possibly breasts as well. They usually are unable to produce fertile sperm, meaning reproduction is unlikely.

It is important to note that not all the symptoms listed above are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.

Causes
This variation is caused when the gene called HSD17B3 does not properly provide instructions to an enzyme that is active in testicle production. Because of this, one does not produce testosterone at the same level as males, and thus has more [./https://lgbta.wikia.org/wiki/Feminine femininized] traits outwardly. In a specific area within Israel, [./https://lgbta.wikia.org/wiki/Incestophile incest] and inbreeding is highly common, which causes the genetic development of many individuals to turn out in an unlikely manner. Because of this, 1 in every 100-150 individuals in this area were born with 17-KSR, which is a drastically high amount compared to the average rarity of the variation.

This does not mean that incestual relations is the reason for this variation, but rather means that it can intensify the likelihood of it in development.

Flag
The flag was created on April 27, 2021 by FANDOM user Ariathatsme. The meaning goes as follows: pink-grey for outward femininity, grey for being within the grey-area and change, and blue for inner [./https://lgbta.wikia.org/wiki/Masculine masculinity]. It was made to look similar to the [./https://lgbta.wikia.org/wiki/De_La_Chapelle_Syndrome De La Chapelle Syndrome] flag.

Resources

 * https://medlineplus.gov/genetics/condition/17-beta-hydroxysteroid-dehydrogenase-3-deficiency/
 * https://pubmed.ncbi.nlm.nih.gov/17551466/
 * https://en.wikipedia.org/wiki/17%CE%B2-Hydroxysteroid_dehydrogenase_III_deficiency